Where and when?:
The 6th annual meeting of the Autophagy UK network will be held online on 26th and 27th May 2021. Joining details will be emailed to participants prior to the beginning of the meeting. Please read all of the instructions before the meeting starts.
invited speakers:
- David Rubinsztein, Cambridge Institute for Medical Research (UK) “Autophagy and neurodegeneration”
- Tassula Proikas-Cezanne, University of Tuebingen (DE) “Regulation of WIPI1 at the onset of autophagy”
- Carmine Settembre, TIGEM (IT) “ER-phagy: mechanisms, regulations and functions”
We are gratEful for the support of the following sponsors:
MEETING programme:
Day 1
09.15 – 9.30 Welcome and housekeeping: Jon Lane & Berni Carroll
09.30 – 10.15 Tassula Proikas-Cezanne (Tuebingen, Germany): “Regulation of WIPI1 at the onset of autophagy”. Host: Jon Lane
10.15 – 11.00 Session 1: Molecules & mechanisms I (Jon Lane)
Jo Durgan (Cambridge, UK): “Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine (PS)”
Thanh Nguyen (Monash, Australia): “Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system”
Lucia Sedlackova (Newcastle, UK): “Autophagy promotes cell and organismal survival by maintaining NAD(H) levels”
11:00 – 11:30 Coffee break
11:30 – 12.30 Session 2: Molecules & mechanisms II (Viktor Korolchuk)
Jobert Vargas (London, UK): “NDP52 and TBK1 control the spatiotemporal activation of ULK1 during mitophagy”
Dorotea Fracchiolla (Vienna, Austria): “A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy”
Agata Makar (Edinburgh, UK): “Distinct lysosomal degradation of autophagic and endocytic cargo”
Rachel Curnock (Bristol, UK): “mTORC1-associated lipid homeostasis and cholesterol sensing are perturbed in senescence”
13.00 – 15.00 Posters 1
15.00 – 16.00 Session 3: Selective autophagy (David McEwan)
Lea Wilhelm (Dundee, UK): “NIX co-ordinates clearance of mitochondria and peroxisomes”
Vinay Eapen (Boston, USA): “Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy”
Emma Rusilowicz-Jones (Liverpool, UK): “Benchmarking USP30 inhibitors for enhancement of mitophagy and pexophagy”
Eliona Tsefou (London, UK): “Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches”
16.00 – 16.30 Coffee break
16.30 – 17:30 Plenary lecture: David Rubinzstein: “Autophagy and neurodegeneration” Host: Jon Lane
Day 2
09.15 – 9.30 Welcome and housekeeping: Jon Lane & Berni Carroll
09.30 – 10:15 Carmine Settembre: “ER-phagy: mechanisms, regulations & functions” Host: Berni Carroll
10:15 – 11.00 Session 4: Development/disease (Berni Carroll)
Lisa-Nicole Kiani (London, UK): “Zebrafish model of lysosomal storage disorder CLN2 disease provides a platform for high-throughput drug screening and identifies a hit compound with therapeutic potential”
Joanna Moss (Bristol, UK): “Autophagy coordinates chondrocyte development and early joint formation in zebrafish”
Ana Lechuga-Vieco (Spain/UK): “Surrogated degradation of cardiomyocyte-derived mitochondria by cardiac macrophages”
11:00 – 11:30 Coffee break
11:30 – 12.45 Session 5: Infection/immunity (Rupert Beale)
Oliver Florey (Cambridge, UK): “Bridging the CASM – V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy”
Dingxi Zhou (Oxford, UK): “Autophagy-mediated transition of interleukin signalling is crucial to CD4+ T cell proliferation”
Pangiotis Tsapras (Warwick, UK): “Selective Autophagy Controls Innate Immune Response through a Tak1/Tab2/Sh3px1 axis”
Melanie Krause (London, UK): “Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62”
Nora Mellouk (Toronto, Canada): “An ATG16L1-dependent pathway promotes plasma membrane repair and limits pathogen spread”
13.00 – 15.00 Posters 2
15:00 – 15:15 Prizes; meeting close: Jon Lane & Berni Carroll
Registration:
Registration is closed.
Abstracts (deadline 21st May 2021):
Abstract submission for consideration for a short talk has now closed.
For people already registered we are happy to accept your abstracts for poster presentations. Please submit these Word documents to autophagyuk2021@gmail.com by 21st May 2021.
There are no formal requirements for the abstract but please ensure you include a title and the names and affiliations of all contributing authors. Please keep the abstracts to a sensible length of ~250 words. We welcome abstracts on any area of autophagy research.
For those who have submitted abstracts for short talks, we will let you know by 14th May whether you have been selected. Abstracts will be selected for either a poster or oral presentation by the organising committee.
Any questions?:
Please contact the dedicated meeting email address at autophagyuk2021@gmail.com or email the organisers directly; Jon Lane (jon.lane@bristol.ac.uk) or Berni Carroll (bernadette.carroll@bristol.ac.uk).
