2021 Meeting – Online

Registration is closed – follow @AutophagyUK for updates. 

Where and when?:

The 6th annual meeting of the Autophagy UK network will be held online on 26th and 27th May 2021. Joining details will be emailed to participants prior to the beginning of the meeting. Please read all of the instructions before the meeting starts.

invited speakers:

  • David Rubinsztein, Cambridge Institute for Medical Research (UK) “Autophagy and neurodegeneration”
  • Tassula Proikas-Cezanne, University of Tuebingen (DE) “Regulation of WIPI1 at the onset of autophagy”
  • Carmine Settembre, TIGEM (IT) “ER-phagy: mechanisms, regulations and functions”

We are gratEful for the support of the following sponsors:

MEETING programme:

Day 1

09.15 – 9.30      Welcome and housekeeping: Jon Lane & Berni Carroll

09.30 – 10.15    Tassula Proikas-Cezanne (Tuebingen, Germany): “Regulation of WIPI1 at the onset of autophagy”. Host: Jon Lane

10.15 – 11.00    Session 1: Molecules & mechanisms I (Jon Lane)

Jo Durgan (Cambridge, UK): “Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine (PS)

Thanh Nguyen (Monash, Australia): “Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

Lucia Sedlackova (Newcastle, UK): “Autophagy promotes cell and organismal survival by maintaining NAD(H) levels

11:00 – 11:30    Coffee break

11:30 – 12.30    Session 2: Molecules & mechanisms II (Viktor Korolchuk)

Jobert Vargas (London, UK): “NDP52 and TBK1 control the spatiotemporal activation of ULK1 during mitophagy

Dorotea Fracchiolla (Vienna, Austria): “A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

Agata Makar (Edinburgh, UK): “Distinct lysosomal degradation of autophagic and endocytic cargo

Rachel Curnock (Bristol, UK): “mTORC1-associated lipid homeostasis and cholesterol sensing are perturbed in senescence

13.00 – 15.00    Posters 1

15.00 – 16.00    Session 3: Selective autophagy (David McEwan)

Lea Wilhelm (Dundee, UK): “NIX co-ordinates clearance of mitochondria and peroxisomes

Vinay Eapen (Boston, USA): “Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

Emma Rusilowicz-Jones (Liverpool, UK): “Benchmarking USP30 inhibitors for enhancement of mitophagy and pexophagy

Eliona Tsefou (London, UK): “Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

16.00 – 16.30    Coffee break

16.30 – 17:30    Plenary lecture: David Rubinzstein: “Autophagy and neurodegenerationHost: Jon Lane

Day 2

09.15 – 9.30    Welcome and housekeeping: Jon Lane & Berni Carroll

09.30 – 10:15    Carmine Settembre: “ER-phagy: mechanisms, regulations & functions”   Host: Berni Carroll

10:15 – 11.00    Session 4: Development/disease (Berni Carroll)

Lisa-Nicole Kiani (London, UK): “Zebrafish model of lysosomal storage disorder CLN2 disease provides a platform for high-throughput drug screening and identifies a hit compound with therapeutic potential

Joanna Moss (Bristol, UK): “Autophagy coordinates chondrocyte development and early joint formation in zebrafish

Ana Lechuga-Vieco (Spain/UK): “Surrogated degradation of cardiomyocyte-derived mitochondria by cardiac macrophages

11:00 – 11:30    Coffee break

11:30 – 12.45    Session 5: Infection/immunity (Rupert Beale)

Oliver Florey (Cambridge, UK): “Bridging the CASM – V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy

Dingxi Zhou (Oxford, UK): “Autophagy-mediated transition of interleukin signalling is crucial to CD4+ T cell proliferation

Pangiotis Tsapras (Warwick, UK): “Selective Autophagy Controls Innate Immune Response through a Tak1/Tab2/Sh3px1 axis

Melanie Krause (London, UK): “Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62

Nora Mellouk (Toronto, Canada): “An ATG16L1-dependent pathway promotes plasma membrane repair and limits pathogen spread

13.00 – 15.00    Posters 2

15:00 – 15:15    Prizes; meeting close: Jon Lane & Berni Carroll

Registration:

Registration is closed.

Abstracts (deadline 21st May 2021):

Abstract submission for consideration for a short talk has now closed.

For people already registered we are happy to accept your abstracts for poster presentations. Please submit these Word documents to autophagyuk2021@gmail.com by 21st May 2021.

There are no formal requirements for the abstract but please ensure you include a title and the names and affiliations of all contributing authors. Please keep the abstracts to a sensible length of ~250 words. We welcome abstracts on any area of autophagy research.

For those who have submitted abstracts for short talks, we will let you know by 14th May whether you have been selected. Abstracts will be selected for either a poster or oral presentation by the organising committee.

Any questions?:

Please contact the dedicated meeting email address at autophagyuk2021@gmail.com or email the organisers directly; Jon Lane (jon.lane@bristol.ac.uk) or Berni Carroll (bernadette.carroll@bristol.ac.uk).